CNN cited aviation officials saying 48 people were on board the Newark to Buffalo flight. It was not immediately clear if there were casualties.
A 50-seater passenger plane has crashed into a house in Buffalo, New York State, officials have said.
Police official John Manthey told the Associated Press news agency that the plane hit a house at 2220 (0320GMT). The house was engulfed in flames.
Two people with minor injuries not on plane were taken to hospital, CNN said.
Continental Express flight 3407 had reportedly been delayed, and was approaching the airport in Buffalo two hours later than scheduled.
It came down about five miles (8km) from the airport.
Twelve houses near the crash site were evacuated, because of concerns about the fuel left on the crashed plane.
Source: BBCNews
